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Combination Therapy Approved for Chronic Hepatitis C Infection (ASHP - American Society of Health-System Pharmacists)

Next: European Commission Grants Marketing Authorizations for AbbVie's VIEKIRAX® (ombitasvir/paritaprevir/ritonavir tablets) + EXVIERA® (dasabuvir tablets) for the Treatment of Chronic Hepatitis C - In Phase 3 clinical trials, VIEKIRAX + EXVIERA cured 95-100 percent of genotype 1 chronic hepatitis C patients, with less than 2 percent of patients experiencing virologic failure[1],[2]- Tolerability profile shows more than 98 percent of patients completed a full course of therapy[3]- All-oral, interferon-free regimen also approved for HCV/HIV-1 co-infection, patients on opioid substitution therapy and patients who have undergone a liver transplant[1],[2]- VIEKIRAX + EXVIERA are the first products to be approved as a combination treatment of three direct-acting antivirals with distinct mechanisms of action targeting hepatitis C at multiple steps in the viral lifecycle[1],[2]
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(Source: ASHP - American Society of Health-System Pharmacists) BETHESDA, MD 22 Dec 2014- FDA and AbbVie on December 19 announced the approval of Viekira Pak, a four-drug oral combination product for the treatment of chronic hepatitis C infection in adults. Viekira Pak contains three new drugs-ombitasvir, paritaprevir, and dasabuvir-and the antiretroviral drug ritonavir, according to the product's labeling (PDF). Ombitasvir, a hepatitis C virus NS5A inhibitor, is formulated in a fixed-dose combination tablet along with the hepatitis C virus NS3/4A protease inhibitor paritaprevir...

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